THE NEXT GENERATION OF ENCAPSULATION TECHNOLOGY

MARBLEMAT • PHARMA TECH STARTUP

WHAT MARBLEMAT DOES?

SOLID ENCAPSULATION OF OIL MARBLES.

Our strengths lie in the development of lipid formulations (of pharmaceutics, food supplements or cosmetics) in solid state, which inherently exhibit improved handling properties and offer dosing flexibility while maintaining a high oil content.

Our technology is based on oil marbles – round liquid droplets, covered by a highly stable layer of fine solid particles. The powder particles prevent wetting, leakage or coalescence, causing the marbles to behave as individual objects. Their size is uniform and can be varied from 1 to 3 mm, depending on their composition and manufacturing parameters. While a variety of liquids can be encapsulated in this manner, we are mostly focusing on oil-based (lipidic) marbles as an ideal vehicle for poorly water-soluble molecules. In case of formulations containing solid-state lipids, melted liquid marbles are produced in liquid state and subsequently cooled down to solidify.

Due to the technique’s uniqueness, we have developed our own device to produce melt liquid marbles. This device enables us to manufacture precise marbles of desired sizes and compositions, which affects their physical properties. It is currently in the process of being implemented into the GMP regime, which will give us the potential to meet all requirements presented by regulatory authorities.

USE OF MARBLEMAT

LIPID BASED FORMULATION.

Lipid formulations have proven to be able to overcome the food effect in in vivo conditions and to increase the bioavailability of active ingredients, but their handling, dosing and administration are difficult – our solidification process therefore presents an ideal solution to the typical impracticality of otherwise.

Pharma

Our aim is to prepare solid lipid formulation with the Oil Marbles technology, combining all the advantages of lipid-based products with increased processability of solid particles while providing the opportunity of fast development of multiple dosage strengths with possible application in personalized medicine. Additional advantages include possibility of taste masking and modification of dissolution rate by a simple change of geometry.

Cosmetics

The field of cosmetics presents a wide range of possible applications. With our technology we are able to increase precise dosing of active ingredients in creams while offering potential enhancement in attractivity for customers and product differentiation by usage of powder colorants.

Food

With our technology, we are capable of creating solid formulations of food supplements and additives which are otherwise hard to handle. We see the potential for precise addition of valuable nutrition components into customers‘ diets, potentially enhanced by taste modification.

MARBLEMAT BENEFITS

SPHEROMAT WITH PERSONALIZED DOSAGE.

Individual particles with high oil content are perfect to optimize the dosage. Due to the highly customizable thin layer of various solid particles, the release kinetics of encapsulated molecules can be modified. And more?

Bioavailability enhancement – higher drug efficacy, cost savings due to smaller API load required, reduction of undesired adverse effects
Elimination of food effect – increase in patients’ comfort
Release rate modification – adjustment of formulation to achieve requested release kinetics
Solid formulation – easier manipulation
Stabilization of sensitive and reactive components – prolonged shelf life
Precise dosage – individual particles with high oil content and
Precise mixtures – combine individual particles to create precise mixture of multiple active ingredients or release rates
Taste masking – masking of unpleasant taste and odor for consumers’ comfort
Eco-friendly – our technology use only biodegradable ingredients and no solvents
Low temperature process – maximum temperature of 60°C for limited time to protect heat-sensitive components
Flexible process – easy incorporation into existing production line, fast scale-up and scale-down, quick transformation for different products production

SCIENCE BEHIND MARBLEMAT

The technology of oil marbles was developed at the University of chemistry and technology, Prague at the Chobotix Lab. During recent years, the team constructed the pilot device Spheromat for manufacturing of precise oil marbles (between 1 to 3 mm in diameter). Huge technological progress was made through the TAČR Zeta grant, during which a semi-industrial scale Spheromat device was developed. In addition, several research papers have been published in prestigious international scientific journals. Thanks to the wide range of external and internal experts in our team we are able to deliver the expertise of pharmaceutical development. Marblemat is still in a close connection with university that give us the innovation spirit.