UPGRADE YOUR

PERSONALIZATION

AND EFFICIENCY

WITH INNOVATIVE

SOLID LIPID PARTICLES

UPGRADE YOUR
PERSONALIZATION AND EFFICIENCY
WITH INNOVATIVE SOLID LIPID PARTICLES

WHAT MARBLEMAT DOES?

MarbleMat offers contract research that includes active ingredient implementation using our technology and basic testing.

SOLID

ENCAPSULATION

OF OIL

MARBLES

SOLID ENCAPSULATION OF OIL MARBLES

Our strengths lie in the development of lipid formulations (of pharmaceutics, food supplements or cosmetics) in solid state, which inherently exhibit improved handling properties and offer dosing flexibility while maintaining a high oil content.

Our technology is based on oil marbles – round liquid droplets, covered by a highly stable layer of fine solid particles. The powder particles prevent wetting, leakage or coalescence, causing the marbles to behave as individual objects. Their size is uniform and can be varied from 1 to 3 mm, depending on their composition and manufacturing parameters. While a variety of liquids can be encapsulated in this manner, we are mostly focusing on oil-based (lipidic) marbles as an ideal vehicle for poorly water-soluble molecules. In case of formulations containing solid-state lipids, melted liquid marbles are produced in liquid state and subsequently cooled down to solidify.

Due to the technique’s uniqueness, we have developed our own device to produce melt liquid marbles. This device enables us to manufacture precise marbles of desired sizes and compositions, which affects their physical properties. It is currently in the process of being implemented into the GMP regime, which will give us the potential to meet all requirements presented by regulatory authorities.

USE OF MARBLEMAT

Lipid formulations have proven to be able to overcome the food effect in in vivo conditions and to increase the bioavailability of active ingredients, but their handling, dosing and administration are difficult – our solidification process therefore presents an ideal solution to the typical impracticality of otherwise.

Pharma

Our aim is to prepare solid lipid formulation with the Oil Marbles technology, combining all the advantages of lipid-based products with increased processability of solid particles while providing the opportunity of fast development of multiple dosage strengths with possible application in personalized medicine. Additional advantages include possibility of taste masking and modification of dissolution rate by a simple change of geometry.

Pharma

Our aim is to prepare solid lipid formulation with the Oil Marbles technology, combining all the advantages of lipid-based products with increased processability of solid particles while providing the opportunity of fast development of multiple dosage strengths with possible application in personalized medicine. Additional advantages include possibility of taste masking and modification of dissolution rate by a simple change of geometry.

Cosmetics

Theo field of cosmetics presents a wide range of possible applications. With our technology we are able to increase precise dosing of active ingredients in creams while offering potential enhancement in attractivity for customers and product differentiation by usage of powder colorants.

Cosmetics

Theo field of cosmetics presents a wide range of possible applications. With our technology we are able to increase precise dosing of active ingredients in creams while offering potential enhancement in attractivity for customers and product differentiation by usage of powder colorants.

Food

With our technology, we are capable of creating solid formulations of food supplements and additives which are otherwise hard to handle. We see the potential for precise addition of valuable nutrition components into customers‘ diets, potentially enhanced by taste modification.

Food

With our technology, we are capable of creating solid formulations of food supplements and additives which are otherwise hard to handle. We see the potential for precise addition of valuable nutrition components into customers‘ diets, potentially enhanced by taste modification.

OUR BENEFITS

Bioavailability enhancement – higher drug efficacy, cost savings due to smaller API load required, reduction of undesired adverse effects

Elimination of food effect – increase in patients’ comfort

Release rate modification – adjustment of formulation to achieve requested release kinetics

Solid formulation – easier manipulation

Prolonged shelf life – stabilization of sensitive and reactive components

Precise dosage – individual particles with high oil content

SPHEROMAT

WITH the

PERSONALIZED

DOSAGE

SPHEROMAT WITH THE PERSONALIZED DOSAGE

Precise mixtures – combine individual particles to create precise mixture of multiple active ingredients or release rates

Taste masking – masking of unpleasant taste and odor for consumers’ comfort

Eco-friendly – our technology use only biodegradable ingredients and no solvents

Low temperature process – maximum temperature of 60°C for limited time to protect heat-sensitive components

Flexible process – easy incorporation into existing production line, fast scale-up and scale-down, quick transformation for different products production

SCIENCE BEHIND MARBLEMAT

The technology of oil marbles was developed at the University of chemistry and technology, Prague at the Chobotix Lab. During recent years, the team constructed the pilot device Spheromat for manufacturing of precise oil marbles (between 1 to 3 mm in diameter). Huge technological progress was made through the TAČR Zeta grant, during which a semi-industrial scale Spheromat device was developed. In addition, several research papers have been published in prestigious international scientific journals. Thanks to the wide range of external and internal experts in our team we are able to deliver the expertise of pharmaceutical development. Marblemat is still in a close connection with university that give us the innovation spirit.

Bioavailability Enhancement and Food Effect Elimination

Operating Limits and Parametric Sensitivity

Manufacturability of Surfactant-Enriched Oil Marbles